RPL11 Antikörper (C-Term)

Produktnummer ABIN6257632

Produktdetails anti-RPL11 Antikörper

Target: RPL11 (Ribosomal Protein L11 (RPL11))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPL11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: RPL11 Antibody detects endogenous levels of total RPL11.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RPL11, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu RPL11

Target: RPL11 (Ribosomal Protein L11 (RPL11))

Andere Bezeichnung: RPL11 (RPL11 Produkte)

Synonyme: DBA7 antikoerper, GIG34 antikoerper, L11 antikoerper, 2010203J19Rik antikoerper, BcDNA:LD17235 antikoerper, CG7726 antikoerper, DL11 antikoerper, Dmel\\CG7726 antikoerper, EST A antikoerper, RPL11 antikoerper, Rp L11 antikoerper, l(2)k16914 antikoerper, rpl11 antikoerper, zgc:86748 antikoerper, ribosomal protein L11 antikoerper, 50S ribosomal protein L11 antikoerper, Ribosomal protein L11 antikoerper, ribosomal protein L11 L homeolog antikoerper, cap binding complex dependent translation initiation factor antikoerper, RPL11 antikoerper, Rpl11 antikoerper, rpl11 antikoerper, RpL11 antikoerper, rpl11.L antikoerper, CTIF antikoerper

Hintergrund:

Description: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity).

Gene: RPL11

Molekulargewicht: 20 kDa

Gen-ID: 6135

UniProt: P62913