ITGB1BP1 Antikörper (Internal Region)

Produktnummer ABIN6257362

Produktdetails anti-ITGB1BP1 Antikörper

Target: ITGB1BP1 (Integrin beta 1 Binding Protein 1 (ITGB1BP1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITGB1BP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: ITBP1 Antibody detects endogenous levels of total ITBP1.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ITBP1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu ITGB1BP1

Target: ITGB1BP1 (Integrin beta 1 Binding Protein 1 (ITGB1BP1))

Andere Bezeichnung: ITGB1BP1 (ITGB1BP1 Produkte)

Synonyme: si:dkey-27p7.1 antikoerper, zgc:123198 antikoerper, ICAP-1A antikoerper, ICAP-1B antikoerper, ICAP-1alpha antikoerper, ICAP1 antikoerper, ICAP1A antikoerper, ICAP1B antikoerper, AI449260 antikoerper, AU019480 antikoerper, Icap1 antikoerper, integrin subunit beta 1 binding protein 1 antikoerper, integrin beta 1 binding protein 1 antikoerper, Itgb1bp1 antikoerper, itgb1bp1 antikoerper, ITGB1BP1 antikoerper

Hintergrund:

Description: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion, inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion, reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation, modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development, acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.

Gene: ITGB1BP1

Gen-ID: 9270

UniProt: O14713

Pathways: Tube Formation