GRLF1 Antikörper (pTyr1105)

Produktnummer ABIN6256617

Produktdetails anti-GRLF1 Antikörper

Target: GRLF1 (Glucocorticoid Receptor DNA Binding Factor 1 (GRLF1))

Bindungsspezifität: pTyr1105

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRLF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: Phospho-GRF-1 (Tyr1105) Antibody detects endogenous levels of GRF-1 only when phosphorylated at Tyrosine 1105.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human GRF-1 around the phosphorylation site of Tyr1105.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu GRLF1

Target: GRLF1 (Glucocorticoid Receptor DNA Binding Factor 1 (GRLF1))

Andere Bezeichnung: ARHGAP35 (GRLF1 Produkte)

Synonyme: GRF-1 antikoerper, GRLF1 antikoerper, P190-A antikoerper, P190A antikoerper, p190ARhoGAP antikoerper, p190RhoGAP antikoerper, 6430596G11Rik antikoerper, AI841135 antikoerper, Arhgap35 antikoerper, mKIAA1722 antikoerper, p190A antikoerper, Grlf1 antikoerper, p190-A antikoerper, arhgap35 antikoerper, grf-1 antikoerper, grlf1 antikoerper, p190-a antikoerper, p190a antikoerper, p190arhogap antikoerper, p190rhogap antikoerper, Rho GTPase activating protein 35 antikoerper, Rho GTPase activating protein 35 L homeolog antikoerper, ARHGAP35 antikoerper, Arhgap35 antikoerper, arhgap35.L antikoerper

Hintergrund:

Description: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3', this function is however unclear and would need additional experimental evidences (PubMed:1894621).

Gene: ARHGAP35

Molekulargewicht: 155kDa

Gen-ID: 2909

UniProt: Q9NRY4

Pathways: Tube Formation