SAMHD1 Antikörper (pThr592)
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- Target Alle SAMHD1 Antikörper anzeigen
- SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))
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Bindungsspezifität
- pThr592
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SAMHD1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- Phospho-SAMHD1 (Thr592) Antibody detects endogenous levels of SAMHD1 only when phosphorylated at Thr592.
- Aufreinigung
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human SAMHD1 around the phosphorylation site of Thr592.
- Isotyp
- IgG
- Top Product
- Discover our top product SAMHD1 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))
- Andere Bezeichnung
- SAMHD1 (SAMHD1 Produkte)
- Synonyme
- CHBL2 antikoerper, DCIP antikoerper, HDDC1 antikoerper, MOP-5 antikoerper, SBBI88 antikoerper, si:dkeyp-44b8.8 antikoerper, E330031J07Rik antikoerper, Mg11 antikoerper, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 antikoerper, SAM domain and HD domain 1 antikoerper, SAM domain and HD domain, 1 antikoerper, SAMHD1 antikoerper, samhd1 antikoerper, Samhd1 antikoerper
- Hintergrund
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Description: Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling (PubMed:18546154, PubMed:19525956, PubMed:22056990, PubMed:24336198, PubMed:28229507). Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction (PubMed:25038827).
Gene: SAMHD1
- Molekulargewicht
- 72kDa
- Gen-ID
- 25939
- UniProt
- Q9Y3Z3
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