ACER2 Antikörper

Produktnummer ABIN6241552

Produktdetails anti-ACER2 Antikörper

Target: ACER2 (Alkaline Ceramidase 2 (ACER2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACER2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Immunogen: Synthetic Peptide

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Details zu ACER2

Target: ACER2 (Alkaline Ceramidase 2 (ACER2))

Andere Bezeichnung: ASAH3L (ACER2 Produkte)

Synonyme: ASAH3L antikoerper, asah3l antikoerper, ALKCDase2 antikoerper, 2410116I05Rik antikoerper, Asah3l antikoerper, CRG-L1 antikoerper, maCER2 antikoerper, alkaline ceramidase 2 antikoerper, alkaline ceramidase 2 S homeolog antikoerper, ACER2 antikoerper, acer2.S antikoerper, acer2 antikoerper, Acer2 antikoerper

Hintergrund: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.

UniProt: Q5QJU3

Pathways: Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process