eIF4EBP1 Antikörper (pSer111)

Produktnummer ABIN6241036

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-eIF4EBP1 Antikörper (Klon RB13351) (ABIN6241036) detektiert spezifisch eIF4EBP1 in DB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für eIF4EBP1 Antikörper (pSer111) (ABIN6241036)

Target: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser eIF4EBP1 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: RB13351

Produktdetails anti-eIF4EBP1 Antikörper

Bindungsspezifität: pSer111

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EIF4EBP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S111 of human EIF4EBP1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-eIF4EBP1 Antikörper (ABIN6241036)

Romasko, Amarnath, Midic, Latham: "Association of maternal mRNA and phosphorylated EIF4EBP1 variants with the spindle in mouse oocytes: localized translational control supporting female meiosis in mammals." in: Genetics, Vol. 195, Issue 2, pp. 349-58, (2014) (PubMed).

Details zu eIF4EBP1

Target: eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Andere Bezeichnung: EIF4EBP1

Hintergrund: EIF4EBP1 is a member of a family of translation repressor proteins. This protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of EIF4EBP1 with eIF4E inhibits complex assembly and represses translation. EIF4EBP1 is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Molekulargewicht: 12580

NCBI Accession: NP_004086

UniProt: Q13541

Pathways: MAPK Signalweg, PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Regulation of Cell Size, BCR Signaling