ATRX Antikörper (CF®640R)

Produktnummer ABIN6189883

Produktdetails anti-ATRX Antikörper (CF®640R)

Target: ATRX (helicase 2, X-linked (ATRX))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATRX Antikörper ist konjugiert mit CF®640R

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunostaining (ISt)

Verwendungszweck: Mouse Monoclonal anti-ATRX / RAD54 (39f), CF640R Conjugate

Produktmerkmale: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 ? to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with ? thalassemia or ATRX syndrome Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human ATRX protein

Klon: 39f

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Immunohistology (formalin) 0.5-1 μg/mL

• Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA Buffer  pH 9.0for 10-20 min followed by cooling at RT for 20 min
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Immunofluorescence 1-2 μg/mL
• Western blotting 0.5-1 μg/mL
• Optimal dilution for a specific application should be determined by user

Kommentare:

Raji, HeLa or A431 Cells. Pancreas, Adrenal, Ovary, Kidney, Prostate or Stomach.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Details zu ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Andere Bezeichnung: ATRX / RAD54 (ATRX Produkte)

Synonyme: ATR2 antikoerper, JMS antikoerper, MRXHF1 antikoerper, RAD54 antikoerper, RAD54L antikoerper, SFM1 antikoerper, SHS antikoerper, XH2 antikoerper, XNP antikoerper, ZNF-HX antikoerper, 4833408C14Rik antikoerper, AI447451 antikoerper, DXHXS6677E antikoerper, HP1-BP38 antikoerper, Hp1bp2 antikoerper, Hp1bp38 antikoerper, MRXS3 antikoerper, Rad54 antikoerper, Xnp antikoerper, atrx antikoerper, rad54 antikoerper, atrxl antikoerper, wu:fb26e12 antikoerper, wu:fb52h08 antikoerper, wu:fb72g09 antikoerper, wu:fb94e07 antikoerper, zgc:66223 antikoerper, ATRX, chromatin remodeler antikoerper, alpha thalassemia/mental retardation syndrome X-linked L homeolog antikoerper, alpha thalassemia/mental retardation syndrome X-linked homolog (human) antikoerper, ATRX antikoerper, Atrx antikoerper, atrx.L antikoerper, atrx antikoerper

Molekulargewicht: 280 kDa

Gen-ID: 546, 533526, 653797

UniProt: P46100