UACA Antikörper
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- Target Alle UACA Antikörper anzeigen
- UACA
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser UACA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Verwendungszweck
- Mouse Monoclonal anti-UACA / Nucling (AE-5), Purified, BSA-free
- Produktmerkmale
- UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Aufreinigung
- Purified
- Immunogen
- Nuclei of myeloid leukemia biopsy cells
- Klon
- AE-5
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product UACA Primärantikörper
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- Applikationshinweise
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Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 0.5-1.0 μg/mL
- Western blotting 0.5-1 μg/mL
- Optimal dilution for a specific application should be determined by user
- Kommentare
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HeLa or 293T cells. Highly expressed in skeletal muscle, heart, kidney and pancreas. Also expressed in epidermal melanocytes, eye muscles and thyroid follicular cells.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS (no BSA, no azide)
- Konservierungsmittel
- Azide free
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- Target
- UACA
- Andere Bezeichnung
- UACA / Nucling (UACA Produkte)
- Synonyme
- NUCLING antikoerper, 2700059D02Rik antikoerper, nucling antikoerper, RGD1560011 antikoerper, uveal autoantigen with coiled-coil domains and ankyrin repeats antikoerper, UACA antikoerper, Uaca antikoerper
- Hintergrund
- Nuclear membrane binding protein, Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA), NUCLING
- Molekulargewicht
- 160 kDa
- Gen-ID
- 55075, 108049
- UniProt
- Q9BZF9
- Pathways
- Positive Regulation of Endopeptidase Activity
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