APOBEC3G Antikörper (C-Term)

Produktnummer ABIN615432

Produktdetails anti-APOBEC3G Antikörper

Target: APOBEC3G (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser APOBEC3G Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequenz: C-DEHSQDLSGR LR

Spezifität: This antibody detects APOBEC3G (C-term).

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide from the C Terminus of the protein sequence according to NP_068594.1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu APOBEC3G

Target: APOBEC3G (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G))

Andere Bezeichnung: APOBEC3G (APOBEC3G Produkte)

Synonyme: A3G antikoerper, ARCD antikoerper, ARP-9 antikoerper, ARP9 antikoerper, CEM-15 antikoerper, CEM15 antikoerper, bK150C2.7 antikoerper, dJ494G10.1 antikoerper, apolipoprotein B mRNA editing enzyme catalytic subunit 3G antikoerper, APOBEC3G antikoerper

Hintergrund: The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G, a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.Synonyms: APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, ARP9, CEM15, DNA dC->dU-editing enzyme APOBEC-3G, MDS019

Gen-ID: 60489

NCBI Accession: NP_068594

UniProt: Q9HC16