PSTPIP1 Antikörper (AA 157-416)

Produktnummer ABIN6146369

Produktdetails anti-PSTPIP1 Antikörper

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Bindungsspezifität: AA 157-416

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSTPIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: AFERISANGH QKQVEKSQNK ARQCKDSATE AERVYRQSIA QLEKVRAEWE QEHRTTCEAF QLQEFDRLTI LRNALWVHSN QLSMQCVKDD ELYEEVRLTL EGCSIDADID SFIQAKSTGT EPPAPVPYQN YYDREVTPLT SSPGIQPSCG MIKRFSGLLH GSPKTTSLAA SAASTETLTP TPERNEGVYT AIAVQEIQGN PASPAQEYRA LYDYTAQNPD ELDLSAGDIL EVILEGEDGW WTVERNGQRG FVPGSYLEKL

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_003969.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PSTPIP1

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Andere Bezeichnung: PSTPIP1 (PSTPIP1 Produkte)

Synonyme: cd2bp1 antikoerper, cd2bp1l antikoerper, cd2bp1s antikoerper, h-pip antikoerper, papas antikoerper, pstpip antikoerper, PSTPIP1 antikoerper, CD2BP1 antikoerper, CD2BP1L antikoerper, CD2BP1S antikoerper, H-PIP antikoerper, PAPAS antikoerper, PSTPIP antikoerper, def-2 antikoerper, proline-serine-threonine phosphatase interacting protein 1 antikoerper, proline-serine-threonine phosphatase interacting protein 1 S homeolog antikoerper, proline-serine-threonine phosphatase-interacting protein 1 antikoerper, PSTPIP1 antikoerper, pstpip1.S antikoerper, pstpip1 antikoerper, Pstpip1 antikoerper

Hintergrund: This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.,PSTPIP1,CD2BP1,CD2BP1L,CD2BP1S,H-PIP,PAPAS,PSTPIP,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,PSTPIP1

Molekulargewicht: 45 kDa/47 kDa

Gen-ID: 9051

UniProt: O43586