Factor VIII Antikörper

Produktnummer ABIN614478

Der Maus Monoklonal anti-Factor VIII Antikörper (Klon n-a) (ABIN614478) detektiert spezifisch Factor VIII in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Factor VIII Antikörper (ABIN614478)

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Factor VIII Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: N-a

Produktdetails anti-Factor VIII Antikörper

Spezifität: This antibody recognizes full-length Human Factor VIII (F8). Does not cross-react with von Willebrand factor.

Aufreinigung: Protein G chromatography

Immunogen: F8 antibody was raised against purified human Factor VIII.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.73 mg/mL

Buffer: PBS, pH 7.4

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C to -70 °C.

Details zu Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Hintergrund: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.Synonyms: AHF, Antihemophilic factor, F8C, Procoagulant component

Gen-ID: 2157

NCBI Accession: NP_000123

UniProt: P00451