HFE2 Antikörper (AA 1-174)

Produktnummer ABIN6141738

Produktdetails anti-HFE2 Antikörper

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Bindungsspezifität: AA 1-174

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HFE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MQECIDQKVY QAEVDNLPVA FEDGSINGGD RPGGSSLSIQ TANPGNHVEI QAAYIGTTII IRQTAGQLSF SIKVAEDVAM AFSAEQDLQL CVGGCPPSQR LSRSERNRRG AITIDTARRL CKEGLPVEDA YFHSCVFDVL ISGDPNFTVA AQAALEDARA FLPDLEKLHL FPSD

Kreuzreaktivität: Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human HFE2 (NP_998817.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HFE2

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Andere Bezeichnung: HFE2 (HFE2 Produkte)

Synonyme: HFE2A antikoerper, HJV antikoerper, JH antikoerper, RGMC antikoerper, HFE2 antikoerper, DKFZp468F2322 antikoerper, 2310035L15Rik antikoerper, 5230400G09Rik antikoerper, AI414844 antikoerper, AI789733 antikoerper, DL-M antikoerper, Rgmc antikoerper, hemojuvelin antikoerper, RGMr antikoerper, hjv antikoerper, id:ibd3464 antikoerper, wu:fb38f10 antikoerper, zgc:136698 antikoerper, hemochromatosis type 2 (juvenile) antikoerper, hemochromatosis type 2 antikoerper, HFE2 antikoerper, Hfe2 antikoerper, hfe2 antikoerper

Hintergrund: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.,HFE2,HFE2A,HJV,JH,RGMC,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases Markers,Other Neurological disorders,Stem Cells,Amyotrophic lateral sclerosis-ALS,HFE2

Molekulargewicht: 21 kDa/33 kDa/45 kDa

Gen-ID: 148738

UniProt: Q6ZVN8

Pathways: Transition Metal Ion Homeostasis