FBXW7 Antikörper (AA 408-707)

Produktnummer ABIN6140535

Produktdetails anti-FBXW7 Antikörper

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Bindungsspezifität: AA 408-707

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: AVTGKCLRTL VGHTGGVWSS QMRDNIIISG STDRTLKVWN AETGECIHTL YGHTSTVRCM HLHEKRVVSG SRDATLRVWD IETGQCLHVL MGHVAAVRCV QYDGRRVVSG AYDFMVKVWD PETETCLHTL QGHTNRVYSL QFDGIHVVSG SLDTSIRVWD VETGNCIHTL TGHQSLTSGM ELKDNILVSG NADSTVKIWD IKTGQCLQTL QGPNKHQSAV TCLQFNKNFV ITSSDDGTVK LWDLKTGEFI RNLVTLESGG SGGVVWRIRA SNTKLVCAVG SRNGTEETKL LVLDFDVDMK

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 408-707 of human FBXW7 (NP_361014.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Andere Bezeichnung: FBXW7 (FBXW7 Produkte)

Synonyme: cdc4 antikoerper, AGO antikoerper, CDC4 antikoerper, FBW6 antikoerper, FBW7 antikoerper, FBX30 antikoerper, FBXO30 antikoerper, FBXW6 antikoerper, SEL-10 antikoerper, SEL10 antikoerper, hAgo antikoerper, hCdc4 antikoerper, 1110001A17Rik antikoerper, Cdc4 antikoerper, Fbw7 antikoerper, Fbwd6 antikoerper, Fbx30 antikoerper, Fbxo30 antikoerper, Fbxw6 antikoerper, F-box and WD repeat domain containing 7 antikoerper, F-box and WD-40 domain protein 7 antikoerper, Fbxw7 antikoerper, FBXW7 antikoerper, fbxw7 antikoerper

Hintergrund: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class, in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.,FBXW7,AGO,CDC4,FBW6,FBW7,FBX30,FBXO30,FBXW6,SEL-10,SEL10,hAgo,hCdc4,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,FBXW7

Molekulargewicht: 66 kDa/70 kDa/79 kDa

Gen-ID: 55294

UniProt: Q969H0

Pathways: Notch Signalweg, EGFR Signaling Pathway