DNAJB14 Antikörper (AA 1-120)

Produktnummer ABIN6139706

Produktdetails anti-DNAJB14 Antikörper

Target: DNAJB14 (DnaJ (Hsp40) Homolog, Subfamily B, Member 14 (DNAJB14))

Bindungsspezifität: AA 1-120

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNAJB14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MEGNRDEAEK CVEIAREALN AGNREKAQRF LQKAEKLYPL PSARALLEII MKNGSTAGNS PHCRKPSGSG DQSKPNCTKD STSGSGEGGK GYTKDQVDGV LSINKCKNYY EVLGVTKDAG

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DNAJB14 (NP_001026893.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:4000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu DNAJB14

Target: DNAJB14 (DnaJ (Hsp40) Homolog, Subfamily B, Member 14 (DNAJB14))

Andere Bezeichnung: DNAJB14 (DNAJB14 Produkte)

Synonyme: Dnajb14 antikoerper, MGC153638 antikoerper, DKFZp468H1319 antikoerper, EGNR9427 antikoerper, PRO34683 antikoerper, 5730496F10Rik antikoerper, flj14281 antikoerper, DnaJ heat shock protein family (Hsp40) member B14 antikoerper, DnaJ (Hsp40) homolog, subfamily B, member 14 antikoerper, DnaJ heat shock protein family (Hsp40) member B14 S homeolog antikoerper, DNAJB14 antikoerper, dnajb14 antikoerper, Dnajb14 antikoerper, dnajb14.S antikoerper

Hintergrund: Acts as a co-chaperone with HSPA8/Hsc70, required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus, the role of these structures, named DJANGOs, is still unclear.,DNAJB14,EGNR9427,PRO34683,Epigenetics & Nuclear Signaling,Signal Transduction,DNAJB14

Molekulargewicht: 33 kDa/42 kDa

Gen-ID: 79982

UniProt: Q8TBM8