Claudin 18 Antikörper (AA 20-80)

Produktnummer ABIN6138681

Produktdetails anti-Claudin 18 Antikörper

Target: Claudin 18 (CLDN18)

Bindungsspezifität: AA 20-80

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GCIAATGMDM WSTQDLYDNP VTSVFQYEGL WRSCVRQSSG FTECRPYFTI LGLPAMLQAV R

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-80 of human CLDN18 (NP_057453.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Claudin 18

Target: Claudin 18 (CLDN18)

Andere Bezeichnung: CLDN18 (CLDN18 Produkte)

Synonyme: claudin-18 antikoerper, CLDN18 antikoerper, SFTA5 antikoerper, SFTPJ antikoerper, claudin 18 L homeolog antikoerper, claudin 18 antikoerper, cldn18.L antikoerper, CLDN18 antikoerper, Cldn18 antikoerper

Hintergrund: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.,CLDN18,SFTA5,SFTPJ,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Tight Junctions,Cytoskeleton,CLDN18

Molekulargewicht: 27 kDa

Gen-ID: 51208

UniProt: P56856

Pathways: Cell-Cell Junction Organization, Hepatitis C