BMPR2 Antikörper (AA 27-150)

Produktnummer ABIN6137608

Produktdetails anti-BMPR2 Antikörper

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Bindungsspezifität: AA 27-150

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BMPR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: SQNQERLCAF KDPYQQDLGI GESRISHENG TILCSKGSTC YGLWEKSKGD INLVKQGCWS HIGDPQECHY EECVVTTTPP SIQNGTYRFC CCSTDLCNVN FTENFPPPDT TPLSPPHSFN RDET

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-150 of human BMPR2 (NP_001195.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-BMPR2 Antikörper (ABIN6137608)

Shi, Zhu, Wei, Fu, Wang, Liu, Zhang, Liang, Xing, Wang, Wang: "Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition." in: Life sciences, Vol. 207, pp. 442-450, (2018) (PubMed).

Details zu BMPR2

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Andere Bezeichnung: BMPR2 (BMPR2 Produkte)

Synonyme: BMPR-II antikoerper, BMPR3 antikoerper, BMR2 antikoerper, BRK-3 antikoerper, PPH1 antikoerper, T-ALK antikoerper, 2610024H22Rik antikoerper, AL117858 antikoerper, AW546137 antikoerper, BB189135 antikoerper, BMP-2 antikoerper, BMPR-2 antikoerper, BMPRII antikoerper, Gm20272 antikoerper, Bmpr-II antikoerper, bmprii antikoerper, bone morphogenetic protein receptor type 2 antikoerper, bone morphogenetic protein receptor, type II b (serine/threonine kinase) antikoerper, bone morphogenetic protein receptor, type II (serine/threonine kinase) antikoerper, BMPR2 antikoerper, bmpr2b antikoerper, Bmpr2 antikoerper

Hintergrund: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.,BMPR2,BMPR-II,BMPR3,BMR2,BRK-3,POVD1,PPH1,T-ALK,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Bone,Growth factor,Stem Cells,Mesenchymal Stem Cells,Cardiovascular,Heart,Hypertrophy,Receptors,BMPR2

Molekulargewicht: 59 kDa/115 kDa

Gen-ID: 659

UniProt: Q13873

Pathways: Growth Factor Binding