ABCC8 Antikörper (AA 700-1000)

Produktnummer ABIN6136367

Produktdetails anti-ABCC8 Antikörper

Target: ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))

Bindungsspezifität: AA 700-1000

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCC8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TIRIPRGQLT MIVGQVGCGK SSLLLAALGE MQKVSGAVFW SSLPDSEIGE DPSPERETAT DLDIRKRGPV AYASQKPWLL NATVEENIIF ESPFNKQRYK MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHANV VFLDDPFSAL DIHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVTERKAT EPPQGLSRAM SSRDGLLQDE EEEEEEAAES EEDDNLSSML HQRAEIPWRA C

Kreuzreaktivität: Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human ABCC8 (NP_000343.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ABCC8

Target: ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))

Andere Bezeichnung: ABCC8 (ABCC8 Produkte)

Synonyme: ABC36 antikoerper, HHF1 antikoerper, HI antikoerper, HRINS antikoerper, MRP8 antikoerper, PHHI antikoerper, SUR antikoerper, SUR1 antikoerper, SUR1delta2 antikoerper, TNDM2 antikoerper, D930031B21Rik antikoerper, Sur antikoerper, Sur1 antikoerper, ATP binding cassette subfamily C member 8 antikoerper, ATP-binding cassette, sub-family C (CFTR/MRP), member 8 antikoerper, ABCC8 antikoerper, Abcc8 antikoerper

Hintergrund: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.,ABCC8,ABC36,HHF1,HI,HRINS,MRP8,PHHI,SUR,SUR1,SUR1delta2,TNDM2,Cancer,Signal Transduction,Endocrine & Metabolism,Drug metabolism,Endocrine and metabolic diseases,Diabetes,Cardiovascular,Heart,Cardiac arrhythmias,Cardiovascular diseases,Heart disease,ABCC8

Molekulargewicht: 5 kDa/176 kDa/177 kDa

Gen-ID: 6833

UniProt: Q09428

Pathways: Negative Regulation of Hormone Secretion