CMKLR1 Antikörper

Produktnummer ABIN5959097

Produktdetails anti-CMKLR1 Antikörper

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CMKLR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: CHEMERINR,Chemokine like receptor 1,Chemokine-like receptor 1,CHEMR23,CMKLR1,CML1,DEZ,G protein coupled receptor ChemR23,G protein coupled receptor DEZ,G-protein coupled receptor ChemR23,G-protein coupled receptor DEZ,Orphan G protein coupled receptor,Orphan G protein coupled receptor Dez,Resolvin E1 receptor,RVER1

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from the Internal region of human ChemR23

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Andere Bezeichnung: ChemR23 (CMKLR1 Produkte)

Synonyme: CHEMERINR antikoerper, ChemR23 antikoerper, DEZ antikoerper, RVER1 antikoerper, Gpcr27 antikoerper, mcmklr1 antikoerper, si:ch211-240b21.3 antikoerper, CMLKR1 antikoerper, Cmklr-1 antikoerper, GPCR antikoerper, chemerin chemokine-like receptor 1 antikoerper, chemokine-like receptor 1 antikoerper, CMKLR1 antikoerper, Cmklr1 antikoerper, cmklr1 antikoerper

Hintergrund: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Molekulargewicht: 42kDa

Gen-ID: 1240

UniProt: Q99788