Contactin 1 Antikörper (AA 100-150)

Produktnummer ABIN571798

Produktdetails anti-Contactin 1 Antikörper

Target: Contactin 1 (CNTN1)

Bindungsspezifität: AA 100-150

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Contactin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for contactin-1.

Kreuzreaktivität: Human, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from AA 100-150 of human contactin 1 conjugated to an immunogenic carrier protein was used as the antigen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu Contactin 1

Target: Contactin 1 (CNTN1)

Andere Bezeichnung: Contactin 1 (CNTN1 Produkte)

Synonyme: F3 antikoerper, GP135 antikoerper, AW495098 antikoerper, CNTN antikoerper, F3cam antikoerper, F3/F11 antikoerper, cntn-A antikoerper, F11 antikoerper, CNTN1 antikoerper, cntn1 antikoerper, contactin 1 antikoerper, contactin 1 L homeolog antikoerper, contactin 1a antikoerper, CNTN1 antikoerper, Cntn1 antikoerper, cntn1.L antikoerper, cntn1a antikoerper

Hintergrund: FUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. SUBUNIT: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR. SUBCELLULAR LOCATION: Cell membrane, Lipid-anchor, GPI-anchor. MISCELLANEOUS: F3 shares with L1, N-CAM, MAG, and other cell adhesion molecules from nervous tissue the L2/HNK-1 carbohydrate epitope. TISSUE SPECIFICITY: Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.,Contactin Family,Neural cell surface protein F3, F3cam, contactin 1, CNTN1, Glycoprotein gp135

UniProt: Q12860