Nth Endonuclease III-Like 1 (NTHL1) Antikörper

Produktnummer ABIN5706093

Produktdetails

Target: Nth Endonuclease III-Like 1 (NTHL1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: nth endonuclease III-like 1 (E. coli)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Y79 cells were subjected to SDS PAGE followed by western blot with FNab05883(NTHL1 antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Antigendetails

Target: Nth Endonuclease III-Like 1 (NTHL1)

Andere Bezeichnung: NTHL1 (NTHL1 Produkte)

Synonyme: psmc3 antikoerper, psmc3-a antikoerper, nth-like DNA glycosylase 1 S homeolog antikoerper, nthl1.S antikoerper

Hintergrund: Synonyms:NTH1, OCTS3 Background:Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic(AP) lyase function that catalyzes the first step in base excision repair(BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine(8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Molekulargewicht: 34 kDa

Gen-ID: 4913

UniProt: P78549