THO Complex 2 Antikörper

Produktnummer ABIN5705257

Produktdetails anti-THO Complex 2 Antikörper

Target: THO Complex 2 (THOC2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THO Complex 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunofluorescence (IF)

Immunogen: THO complex 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu THO Complex 2

Target: THO Complex 2 (THOC2)

Andere Bezeichnung: THOC2 (THOC2 Produkte)

Synonyme: RGD1561623 antikoerper, THO antikoerper, Tho2 antikoerper, fb73e08 antikoerper, fd21d11 antikoerper, wu:fb73e08 antikoerper, wu:fd21d11 antikoerper, si:bz1o18.2 antikoerper, CXorf3 antikoerper, THO2 antikoerper, dJ506G2.1 antikoerper, hTREX120 antikoerper, 6330441O12Rik antikoerper, D130005M13Rik antikoerper, Gm1139 antikoerper, Gm1793 antikoerper, THO complex 2 antikoerper, Thoc2 antikoerper, THOC2 antikoerper, thoc2 antikoerper

Hintergrund: Synonyms:CXorf3 Background:Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex(EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus(KSHV) intronless mRNAs and infectious virus production. THOC2(and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development.

Gen-ID: 57187

UniProt: Q8NI27