RGMA Antikörper

Produktnummer ABIN5705218

Produktdetails anti-RGMA Antikörper

Target: RGMA (RGM Domain Family, Member A (RGMA))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGMA Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Immunogen: RGM domain family, member A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu RGMA

Target: RGMA (RGM Domain Family, Member A (RGMA))

Andere Bezeichnung: RGMA (RGMA Produkte)

Synonyme: RGM antikoerper, BC059072 antikoerper, C230063O06 antikoerper, repulsive guidance molecule family member a antikoerper, repulsive guidance molecule family member A antikoerper, RGMA antikoerper, Rgma antikoerper

Hintergrund: Synonyms:RGM Background:Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Gen-ID: 56963

UniProt: Q96B86

Pathways: Tube Formation