CHMP1A Antikörper

Produktnummer ABIN5705035

Produktdetails anti-CHMP1A Antikörper

Target: CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHMP1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Immunogen: chromatin modifying protein 1A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab01656(CHMP1A antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu CHMP1A

Target: CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))

Andere Bezeichnung: CHMP1A (CHMP1A Produkte)

Synonyme: CHMP1 antikoerper, PCH8 antikoerper, PCOLN3 antikoerper, PRSM1 antikoerper, VPS46-1 antikoerper, VPS46A antikoerper, 2900018H07Rik antikoerper, Pcoln3 antikoerper, charged multivesicular body protein 1A antikoerper, CHMP1A antikoerper, Chmp1a antikoerper

Hintergrund: Synonyms:CHMP1, CHMP1A, chromatin modifying protein 1A, hVps46 1, KIAA0047, PCOLN3, PRSM1, Vps46 1 Background:Probable peripherally associated component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group(PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

Molekulargewicht: 33 kDa ,25 kDa

Gen-ID: 5119

UniProt: Q9HD42