HNRNPD/AUF1 Antikörper

Produktnummer ABIN5703835

Produktdetails anti-HNRNPD/AUF1 Antikörper

Target: HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNRNPD/AUF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Immunogen: heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab03950(HNRNPD antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu HNRNPD/AUF1

Target: HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))

Andere Bezeichnung: HNRNPD (HNRNPD Produkte)

Synonyme: AUF1 antikoerper, AUF1A antikoerper, HNRPD antikoerper, P37 antikoerper, hnRNPD0 antikoerper, Auf1 antikoerper, Hnrnpd antikoerper, HNRNPD antikoerper, p37 antikoerper, auf1a antikoerper, hnrpd antikoerper, hnrnpd0 antikoerper, C230004L04 antikoerper, Hnrpd antikoerper, wu:fa28b06 antikoerper, zgc:162951 antikoerper, heterogeneous nuclear ribonucleoprotein D antikoerper, heterogeneous nuclear ribonucleoprotein D L homeolog antikoerper, HNRNPD antikoerper, Hnrnpd antikoerper, hnrnpd antikoerper, hnrnpd.L antikoerper

Hintergrund: Synonyms:AUF1,AUF1A,HNRPD,P37,hnRNPD0 Background:Binds with high affinity to RNA molecules that contain AU-rich elements(AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double-and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability(mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Molekulargewicht: 38 kDa and 40 kDa

Gen-ID: 3184

UniProt: Q14103