CTR9 Antikörper
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- Target Alle CTR9 Antikörper anzeigen
- CTR9 (RNA Polymerase-Associated Protein CTR9 Homolog (CTR9))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CTR9 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogen
- Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
- Isotyp
- IgG
- Top Product
- Discover our top product CTR9 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab02062(CTR9 antibody) at dilution of 1:500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- CTR9 (RNA Polymerase-Associated Protein CTR9 Homolog (CTR9))
- Andere Bezeichnung
- CTR9 (CTR9 Produkte)
- Synonyme
- SH2BP1 antikoerper, TSBP antikoerper, p150 antikoerper, p150TSP antikoerper, AA409336 antikoerper, Sh2bp1 antikoerper, Tsbp antikoerper, Tsp antikoerper, mKIAA0155 antikoerper, sh2bp1 antikoerper, p150tsp antikoerper, tsbp antikoerper, fc54a06 antikoerper, wu:fc54a06 antikoerper, CTR9 homolog, Paf1/RNA polymerase II complex component antikoerper, CTR9 homolog, Paf1/RNA polymerase II complex component S homeolog antikoerper, Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) antikoerper, RNA polymerase-associated protein CTR9 homolog antikoerper, CTR9 antikoerper, Ctr9 antikoerper, ctr9.S antikoerper, ctr9 antikoerper, LOC100161197 antikoerper, LOC100163982 antikoerper, LOC100168634 antikoerper, LOC100478349 antikoerper, LOC100543206 antikoerper, LOC100645071 antikoerper
- Hintergrund
- Synonyms:KIAA0155, SH2BP1 Background:Component of the PAF1 complex(PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'-and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4'(H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B(H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono-and trimethylation on histone H3 'Lys-4'(H3K4me3) and dimethylation on histone H3 'Lys-79'(H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4'(H3K4me3) on genes involved in stem cell pluripotency, this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway, may regulate DNA-association of STAT3(By similarity).
- Molekulargewicht
- 130-150 kDa
- Gen-ID
- 9646
- UniProt
- Q6PD62
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance
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