FBXW5 Antikörper
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- Target Alle FBXW5 Antikörper anzeigen
- FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FBXW5 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- F-box and WD repeat domain containing 5
- Isotyp
- IgG
- Top Product
- Discover our top product FBXW5 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab03056( FBXW5 Antibody) at dilution of 1:600
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
- Andere Bezeichnung
- FBXW5 (FBXW5 Produkte)
- Synonyme
- Fbw5 antikoerper, AI159739 antikoerper, F-box and WD repeat domain containing 5 antikoerper, F-box and WD-40 domain protein 5 antikoerper, FBXW5 antikoerper, Fbxw5 antikoerper
- Hintergrund
- Synonyms:FBW5 Background:Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway.
- Molekulargewicht
- 65 kDa
- Gen-ID
- 54461
- UniProt
- Q969U6
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