COMMD1 Antikörper
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- Target Alle COMMD1 Antikörper anzeigen
- COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser COMMD1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- copper metabolism (Murr1) domain containing 1
- Isotyp
- IgG
- Top Product
- Discover our top product COMMD1 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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human liver tissue were subjected to SDS PAGE followed by western blot with FNab01850(COMMD1 antibody) at dilution of 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))
- Andere Bezeichnung
- COMMD1 (COMMD1 Produkte)
- Synonyme
- C2orf5 antikoerper, MURR1 antikoerper, murr1 antikoerper, commd1 antikoerper, si:ch211-213b8.2 antikoerper, DDBDRAFT_0184206 antikoerper, DDBDRAFT_0266452 antikoerper, DDB_0184206 antikoerper, DDB_0266452 antikoerper, COMMD1 antikoerper, MGC114682 antikoerper, AI256843 antikoerper, Murr1 antikoerper, U2/Mu antikoerper, copper metabolism domain containing 1 antikoerper, copper metabolism (Murr1) domain containing 1 antikoerper, COMM domain-containing protein 1 antikoerper, copper metabolism domain containing 1 L homeolog antikoerper, COMM domain containing 1 antikoerper, COMMD1 antikoerper, commd1 antikoerper, comd1 antikoerper, Commd1 antikoerper, commd1.L antikoerper
- Hintergrund
- Synonyms:C2orf5, MURR1 Background:Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes by displacing CAND1, in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2(PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity(PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2(PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel(ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes(PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination(PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization(PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes(PubMed:25355947). Can bind one copper ion per monomer(PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2)(PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1(PubMed:20458141).
- Molekulargewicht
- 21 kDa
- Gen-ID
- 150684
- UniProt
- Q8N668
- Pathways
- Transition Metal Ion Homeostasis
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