EXOSC10 Antikörper

Produktnummer ABIN5702156

Produktdetails anti-EXOSC10 Antikörper

Target: EXOSC10 (Exosome Component 10 (EXOSC10))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXOSC10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Immunogen: exosome component 10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu EXOSC10

Target: EXOSC10 (Exosome Component 10 (EXOSC10))

Andere Bezeichnung: EXOSC10 (EXOSC10 Produkte)

Synonyme: Pmscl2 antikoerper, zgc:55695 antikoerper, pm-scl antikoerper, pm/scl-100 antikoerper, pmscl antikoerper, pmscl2 antikoerper, rrp6 antikoerper, rrp6p antikoerper, EXOSC10 antikoerper, 201.t00018 antikoerper, 21.m02990 antikoerper, DDBDRAFT_0203581 antikoerper, DDBDRAFT_0233752 antikoerper, DDB_0203581 antikoerper, DDB_0233752 antikoerper, PM-Scl antikoerper, PM/Scl-100 antikoerper, PMSCL antikoerper, PMSCL2 antikoerper, RRP6 antikoerper, Rrp6p antikoerper, p2 antikoerper, p3 antikoerper, p4 antikoerper, exosome component 10 antikoerper, 3'-5' exonuclease antikoerper, exosome component 10 L homeolog antikoerper, exosc10 antikoerper, EXOSC10 antikoerper, EHI_021400 antikoerper, BBOV_IV002650 antikoerper, CpipJ_CPIJ003896 antikoerper, CMU_031760 antikoerper, Tsp_05247 antikoerper, exosc10.L antikoerper, Exosc10 antikoerper

Hintergrund: Synonyms:PMSCL, PMSCL2, RRP6 Background:Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity(By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

Gen-ID: 5394

UniProt: Q01780