Deltex Homolog 1 Antikörper

Produktnummer ABIN5701820

Produktdetails anti-Deltex Homolog 1 Antikörper

Target: Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Deltex Homolog 1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: deltex homolog 1 (Drosophila)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu Deltex Homolog 1

Target: Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))

Andere Bezeichnung: DTX1 (DTX1 Produkte)

Synonyme: hDx-1 antikoerper, Fxit1 antikoerper, mKIAA4160 antikoerper, deltex antikoerper, dtx antikoerper, xdtx1 antikoerper, deltex E3 ubiquitin ligase 1 antikoerper, deltex homolog 1 (Drosophila) antikoerper, deltex 1, E3 ubiquitin ligase antikoerper, deltex 1 L homeolog antikoerper, deltex 1 S homeolog antikoerper, DTX1 antikoerper, dtx1 antikoerper, Dtx1 antikoerper, dtx1.L antikoerper, dtx1.S antikoerper

Hintergrund: Synonyms: Background:Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity(By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB(Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Molekulargewicht: 67-72,58-63 kDa

Gen-ID: 1840

UniProt: Q86Y01

Pathways: Notch Signalweg