CHCHD4 Antikörper

Produktnummer ABIN5701518

Produktdetails anti-CHCHD4 Antikörper

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHCHD4 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogen: coiled-coil-helix-coiled-coil-helix domain containing 4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

rat brain tissue were subjected to SDS PAGE followed by western blot with FNab01637( CHCHD4 Antibody) at dilution of 1:1500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu CHCHD4

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Andere Bezeichnung: CHCHD4 (CHCHD4 Produkte)

Synonyme: 2410012P20Rik antikoerper, 2810014D17Rik antikoerper, AI838740 antikoerper, MIA40 antikoerper, TIMM40 antikoerper, mia40 antikoerper, timm40 antikoerper, chchd4 antikoerper, chchd4a antikoerper, fc10g04 antikoerper, wu:fc10g04 antikoerper, zgc:100849 antikoerper, si:dkey-202e22.1 antikoerper, chchd4b antikoerper, CaO19.2977 antikoerper, coiled-coil-helix-coiled-coil-helix domain containing 4 antikoerper, coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog antikoerper, coiled-coil-helix-coiled-coil-helix domain containing 4a antikoerper, coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog antikoerper, Mia40p antikoerper, Chchd4 antikoerper, CHCHD4 antikoerper, chchd4 antikoerper, chchd4.L antikoerper, chchd4a antikoerper, chchd4.S antikoerper, LOC100361898 antikoerper, MIA40 antikoerper

Hintergrund: Synonyms:MIA40 Background:Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1(PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364). Required for the import and folding of small cysteine-containing proteins(small Tim) in the mitochondrial intermembrane space(IMS)(PubMed:16185709, PubMed:19182799, PubMed:21059946). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria(PubMed:16185709, PubMed:19182799, PubMed:21059946). The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS(PubMed:16185709, PubMed:19182799, PubMed:21059946). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system(PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake(PubMed:26387864).

Molekulargewicht: 22-25 kDa

Gen-ID: 131474

UniProt: Q8N4Q1