SNAPIN Antikörper

Produktnummer ABIN5701292

Produktdetails anti-SNAPIN Antikörper

Target: SNAPIN (SNAP-Associated Protein (SNAPIN))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNAPIN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Immunogen: SNAP-associated protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

rat brain tissue were subjected to SDS PAGE followed by western blot with FNab08060( SNAPIN Antibody) at dilution of 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu SNAPIN

Target: SNAPIN (SNAP-Associated Protein (SNAPIN))

Andere Bezeichnung: SNAPIN (SNAPIN Produkte)

Synonyme: SNAPAP antikoerper, si:dkey-222b8.2 antikoerper, SNAPIN antikoerper, BLOC1S7 antikoerper, BLOS7 antikoerper, 25kDa antikoerper, AA407989 antikoerper, AV026596 antikoerper, Bloc1s7 antikoerper, Snap25bp antikoerper, Snapap antikoerper, SNAP associated protein antikoerper, SNAP-associated protein L homeolog antikoerper, SNAP-associated protein antikoerper, SNAPIN antikoerper, snapin.L antikoerper, snapin antikoerper, Snapin antikoerper

Hintergrund: Synonyms:BLOC1S7, SNAP25BP, SNAPAP Background:Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles(LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells(PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor(PubMed:25898167).

Gen-ID: 23557

UniProt: O95295

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis