PSTPIP1 Antikörper

Produktnummer ABIN5698979

Produktdetails anti-PSTPIP1 Antikörper

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSTPIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: proline-serine-threonine phosphatase interacting protein 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

mouse thymus tissue were subjected to SDS PAGE followed by western blot with FNab06903(PSTPIP1 antibody) at dilution of 1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu PSTPIP1

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Andere Bezeichnung: PSTPIP1 (PSTPIP1 Produkte)

Synonyme: cd2bp1 antikoerper, cd2bp1l antikoerper, cd2bp1s antikoerper, h-pip antikoerper, papas antikoerper, pstpip antikoerper, PSTPIP1 antikoerper, CD2BP1 antikoerper, CD2BP1L antikoerper, CD2BP1S antikoerper, H-PIP antikoerper, PAPAS antikoerper, PSTPIP antikoerper, def-2 antikoerper, proline-serine-threonine phosphatase interacting protein 1 antikoerper, proline-serine-threonine phosphatase interacting protein 1 S homeolog antikoerper, proline-serine-threonine phosphatase-interacting protein 1 antikoerper, PSTPIP1 antikoerper, pstpip1.S antikoerper, pstpip1 antikoerper, Pstpip1 antikoerper

Hintergrund: Synonyms:CD2BP1 Background:This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.

Gen-ID: 9051

UniProt: O43586