Inversin Antikörper

Produktnummer ABIN5698917

Produktdetails anti-Inversin Antikörper

Target: Inversin (INVS)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Inversin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: inversin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

MCF7 cells were subjected to SDS PAGE followed by western blot with FNab04369(INVS antibody) at dilution of 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu Inversin

Target: Inversin (INVS)

Andere Bezeichnung: INVS (INVS Produkte)

Synonyme: invs-a antikoerper, INVS antikoerper, MGC140477 antikoerper, inv antikoerper, NPH2 antikoerper, NPHP2 antikoerper, INV antikoerper, Nphp2 antikoerper, RGD1563359 antikoerper, wu:fe47e11 antikoerper, inversin S homeolog antikoerper, inversin antikoerper, Inversin antikoerper, invs.S antikoerper, INVS antikoerper, Bm1_38710 antikoerper, PTRG_09181 antikoerper, EAMY_RS33690 antikoerper, LOAG_11716 antikoerper, invs antikoerper, Invs antikoerper

Hintergrund: Synonyms:INV, NPHP2 Background:Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled(DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8(By similarity). Does not seem to be strictly required for ciliogenesis(By similarity).

Molekulargewicht: 110-115 kDa

Gen-ID: 27130

UniProt: Q9Y283