DTX3L Antikörper

Produktnummer ABIN5698856

Produktdetails anti-DTX3L Antikörper

Target: DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DTX3L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: deltex 3-like (Drosophila)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu DTX3L

Target: DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))

Andere Bezeichnung: DTX3L (DTX3L Produkte)

Synonyme: BBAP antikoerper, RGD1565144 antikoerper, AU042200 antikoerper, BC023741 antikoerper, DTX3L antikoerper, deltex E3 ubiquitin ligase 3L antikoerper, deltex 3-like, E3 ubiquitin ligase antikoerper, probable E3 ubiquitin-protein ligase DTX3 antikoerper, DTX3L antikoerper, Dtx3l antikoerper, LOC100521724 antikoerper

Hintergrund: Synonyms:BBAP Background:Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4(H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation(H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

Molekulargewicht: 84 kDa

Gen-ID: 151636

UniProt: Q8TDB6

Pathways: Notch Signalweg