HIC1 Antikörper

Produktnummer ABIN5697936

Produktdetails anti-HIC1 Antikörper

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: hypermethylated in cancer 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03857( HIC1 Antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Andere Bezeichnung: HIC1 (HIC1 Produkte)

Synonyme: zfHIC1 antikoerper, HIC1 antikoerper, ZBTB29 antikoerper, ZNF901 antikoerper, hic-1 antikoerper, AA408311 antikoerper, HIC-1 antikoerper, hypermethylated in cancer 1 antikoerper, HIC ZBTB transcriptional repressor 1 antikoerper, hic1 antikoerper, HIC1 antikoerper, Hic1 antikoerper

Hintergrund: Synonyms:ZBTB29 Background:Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1(indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

Molekulargewicht: 65-70 kDa

Gen-ID: 3090

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus