CNOT1 Antikörper
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- Target Alle CNOT1 Antikörper anzeigen
- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
- Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CNOT1 Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- CCR4-NOT transcription complex, subunit 1
- Isotyp
- IgG
- Top Product
- Discover our top product CNOT1 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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human brain tissue were subjected to SDS PAGE followed by western blot with FNab01805(CNOT1 antibody) at dilution of 1:800
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
- Andere Bezeichnung
- CNOT1 (CNOT1 Produkte)
- Synonyme
- CDC39 antikoerper, NOT1 antikoerper, NOT1H antikoerper, 6030411K04Rik antikoerper, AA815922 antikoerper, D830048B13 antikoerper, RGD1308009 antikoerper, GB18988 antikoerper, cdc39-like antikoerper, im:7141761 antikoerper, kiaa1007l antikoerper, wu:fc58h04 antikoerper, zgc:152902 antikoerper, CNOT1 antikoerper, not1 antikoerper, cdc39 antikoerper, not1h antikoerper, ad-005 antikoerper, NV18106 antikoerper, CCR4-NOT transcription complex subunit 1 antikoerper, CCR4-NOT transcription complex, subunit 1 antikoerper, CNOT1 antikoerper, Cnot1 antikoerper, LOC412371 antikoerper, cnot1 antikoerper, LOC100114396 antikoerper
- Hintergrund
- Synonyms:CDC39, KIAA1007, NOT1 Background:Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity.
- Molekulargewicht
- 240-250 kDa,174 kDa
- Gen-ID
- 23019
- UniProt
- A5YKK6
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
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