Ataxin 2 Antikörper

Produktnummer ABIN5697111

Produktdetails anti-Ataxin 2 Antikörper

Target: Ataxin 2 (ATXN2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ataxin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogen: ataxin 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00657( Ataxin 2 Antibody) at dilution of 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu Ataxin 2

Target: Ataxin 2 (ATXN2)

Andere Bezeichnung: Ataxin 2 (ATXN2 Produkte)

Synonyme: ASL13 antikoerper, ATX2 antikoerper, SCA2 antikoerper, TNRC13 antikoerper, 9630045M23Rik antikoerper, AW544490 antikoerper, Sca2 antikoerper, ATXN2 antikoerper, MGC115230 antikoerper, ataxin 2 antikoerper, ataxin 2 L homeolog antikoerper, ATXN2 antikoerper, Atxn2 antikoerper, atxn2.L antikoerper

Hintergrund: Synonyms:ataxin 2, ATX2, ATXN2, SCA2, TNRC13 Background:This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 140-150 kDa

Pathways: Ribonucleoprotein Complex Subunit Organization