PSMB9 Antikörper (Internal Region)

Produktnummer ABIN569589

Produktdetails anti-PSMB9 Antikörper

Target: PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Kaninchen, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PSMB9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-RNISYKYRED

Spezifität: Recognizes PSMB9

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Canine (Dog), Cow, Pig, Rabbit.
Species reactivity (tested):Human, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_002791.1.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PSMB9

Target: PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))

Andere Bezeichnung: PSMB9 (PSMB9 Produkte)

Synonyme: LMP2 antikoerper, ring12 antikoerper, MHC-linked antikoerper, psmb9b antikoerper, lmp2 antikoerper, lmp2b antikoerper, psmb9 antikoerper, Lmp-2 antikoerper, Lmp2 antikoerper, PSMB6i antikoerper, RING12 antikoerper, beta1i antikoerper, psmb9-A antikoerper, macropain antikoerper, prosome antikoerper, wu:fa66f04 antikoerper, wu:fj22d05 antikoerper, zgc:91842 antikoerper, psmb9a antikoerper, proteasome subunit beta 9 antikoerper, LMP2 antikoerper, proteasome subunit beta type-9b antikoerper, proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) antikoerper, proteasome subunit beta 9 S homeolog antikoerper, proteasome subunit beta 9a antikoerper, proteasome (prosome, macropain) subunit, beta type, 9a antikoerper, psmb9 antikoerper, PSMB9 antikoerper, psmb9-b antikoerper, Psmb9 antikoerper, psmb9.S antikoerper, psmb9a antikoerper

Hintergrund: Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. LMP2 is a catalytic subunit of the 20S proteasome and, upon interferon gamma-induction, replaces the delta subunit. LMP2 alters the specificity of the 20S proteasome and is critical for the production of MHC class I ligands, production of T-lymphocytes, and is suggested to increase the efficiency of antigen presentation of the immune response. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelman's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).Synonyms: LMP2, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, PSMB6i, Proteasome 20S LMP2, Proteasome chain 7, Proteasome subunit beta type-9, Proteasome subunit beta-1i, RING12, Really interesting new gene 12 protein

Molekulargewicht: 23.3kDa (Human NP_002791.1)

Gen-ID: 5698

NCBI Accession: NP_002791

UniProt: P28065

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA