SERPINB5 Antikörper

Produktnummer ABIN5690554

Produktdetails anti-SERPINB5 Antikörper

Target: SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SERPINB5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: Produced from sera of rabbits immunized with highly pure recombinant Human Maspin. Human Maspin specific antibody was purified by affinity chromatography employing an immobilized Human Maspin matrix.

Anwendungsinformationen

Applikationshinweise: ELISA:

In a sandwich ELISA (using 100 uL/well antibody solution) a concentration of 0.5 - 2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with our biotinylated Anti-Human Maspin as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hMaspin.

Western Blot:
To detect hMaspin by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hMaspin is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Lagerung: -20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-80°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. Avoid repeated freeze-thaw cycles.

Details zu SERPINB5

Target: SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))

Andere Bezeichnung: Maspin (SERPINB5 Produkte)

Synonyme: 1110036M19Rik antikoerper, AI462524 antikoerper, AI646751 antikoerper, Maspin antikoerper, PI-5 antikoerper, Spi7 antikoerper, ovalbumin antikoerper, PI5 antikoerper, maspin antikoerper, Pi5 antikoerper, serine (or cysteine) peptidase inhibitor, clade B, member 5 antikoerper, serpin family B member 5 antikoerper, serpin peptidase inhibitor, clade B (ovalbumin), member 5 S homeolog antikoerper, Serpinb5 antikoerper, SERPINB5 antikoerper, serpinb5.S antikoerper

Hintergrund: Maspin was discovered as a mammary tumor suppressor that is expressed in normal mammary epithelium but lost in most breast cancer cell lines. While maspin is related to the serpin family of serine protease inhibitors, it may not function as a protease inhibitor. It plays an essential role in embryonic development through critical roles in cell adhesion. While the precise mechanism of maspin signaling is unclear, the tumor suppressing activity of maspin has been attributed to its ability to inhibit cell invasion/metastasis and angiogenesis, while promoting apoptosis. Nuclear translocation of active IKKα, has been shown to repress maspin transcription and promote prostate cancer metastasis.

Gen-ID: 5268

UniProt: P36952

Pathways: p53 Signalweg