PTPN5 Antikörper (AA 180-230)

Produktnummer ABIN5690111

Produktdetails anti-PTPN5 Antikörper

Target: PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))

Bindungsspezifität: AA 180-230

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPN5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: PTPN5 antibody is human and mouse reactive.

Aufreinigung: PTPN5 antibody is affinity chromatography purified via peptide column.

Immunogen: PTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5.

The immunogen is located within amino acids 180 - 230 of PTPN5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PTPN5 antibody can be used for detection of PTPN5 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PTPN5 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: PTPN5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu PTPN5

Target: PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))

Andere Bezeichnung: PTPN5 (PTPN5 Produkte)

Synonyme: STEP antikoerper, Step antikoerper, PTPSTEP antikoerper, protein tyrosine phosphatase, non-receptor type 5 antikoerper, ptpn5 antikoerper, PTPN5 antikoerper, Ptpn5 antikoerper

Hintergrund: The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). PTPN5 may play a role in Alzheimer's disease (1).

Molekulargewicht: Predicted: 62 kDa

Observed: 60 kDa

Gen-ID: 84867

NCBI Accession: NP_008837

UniProt: Q86TL6