Rap7a antikoerper, 4921531N22Rik antikoerper, AI789753 antikoerper, AU040360 antikoerper, MGC53808 antikoerper, MGC85522 antikoerper, DAP1 antikoerper, DAP antikoerper, Dap antikoerper, ACYPI007535 antikoerper, DAP-1 antikoerper, dap1a antikoerper, wu:fa16h08 antikoerper, wu:fc06d11 antikoerper, death associated protein antikoerper, death-associated protein antikoerper, death-associated protein S homeolog antikoerper, DAP antikoerper, Dap antikoerper, dap.S antikoerper, dap antikoerper
Hintergrund
DAP Antibody: The Death-associated protein (DAP) is a basic proline-rich 15 kDa protein that as a positive mediator of programmed cell death that is induced by interferon-gamma (1). DAP is also a direct substrate of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Under rich nutrient conditions, mTOR phosphorylates DAP at Ser3 and Ser51, under starvation conditions, these residues are dephosphorylated and DAP is converted into an active suppressor of autophagy (2).