LPP Antikörper (AA 1-109)

Produktnummer ABIN5689866

Produktdetails anti-LPP Antikörper

Target: LPP (Lipoma-preferred partner (LPP))

Bindungsspezifität: AA 1-109

Reaktivität: Human, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LPP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Spezifität: Recognizes human, rat and pig LPP.

Aufreinigung: Antigen affinity purified.

Immunogen: Recombinant human lipoma preferred partner (LPP) (aa 1-109).

Anwendungsinformationen

Applikationshinweise: Immunocytochemistry: (1:500). Immunohistochemistry: (1:500). Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 500 μg/mL

Buffer: Liquid. In PBS containing 0.01 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least 1 year after receipt when stored at -20°C.

Details zu LPP

Target: LPP (Lipoma-preferred partner (LPP))

Andere Bezeichnung: Lipoma Preferred Partner (LPP Produkte)

Synonyme: 9430020K16Rik antikoerper, AA959454 antikoerper, AU024130 antikoerper, B130055L10Rik antikoerper, C79715 antikoerper, D630048H16 antikoerper, LIM domain containing preferred translocation partner in lipoma antikoerper, LPP antikoerper, Lpp antikoerper

Hintergrund: Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.

Gen-ID: 4026

NCBI Accession: NP_001161143

UniProt: Q93052