The antibody has been directly tested for reactivity in immunohistochemistry in rat cortex and retinal sections. It is anticipated that the antibody will also work in mouse sections based on the fact that this species has 100 % homology with the amino acid sequence used as antigen.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
Lagerung
-20 °C
Informationen zur Lagerung
GAT-2 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Target
SLC6A13
(Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 13 (SLC6A13))
GAT3 antikoerper, Gabt3 antikoerper, Gat2 antikoerper, GAT-2 antikoerper, GAT2 antikoerper, solute carrier family 6 (neurotransmitter transporter, GABA), member 13 antikoerper, solute carrier family 6 member 13 antikoerper, Slc6a13 antikoerper, SLC6A13 antikoerper
Hintergrund
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999).