ANGPTL4 Antikörper

Produktnummer ABIN5688825

Produktdetails anti-ANGPTL4 Antikörper

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ANGPTL4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: Recognizes the fibrinogen-like domain (FLD) of human ANGPTL4. Detects a band of ~62  kDa and ~35  kDa by Western blot. Does not cross-react with other ANGPTL family proteins.

Immunogen: Recombinant human ANGPTL4.

Klon: Kairos-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: ELISA: (direct or indirect: 1:2,000-1:5,000). Immunohistochemistry: (paraffin sections (1:100-1:1,000)). Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05 % Tween 20 and 5 % skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions should be determined individually for each application.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. 0.2um-filtered solution in PBS,  pH 7.4. Contains no preservatives.

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least 1 year after receipt when stored at -20°C.

Details zu ANGPTL4

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Andere Bezeichnung: ANGPTL4 (ANGPTL4 Produkte)

Synonyme: ANGPTL2 antikoerper, ARP4 antikoerper, FIAF antikoerper, HFARP antikoerper, NL2 antikoerper, PGAR antikoerper, pp1158 antikoerper, Arp4 antikoerper, Bk89 antikoerper, Fiaf antikoerper, Hfarp antikoerper, Ng27 antikoerper, Pgar antikoerper, Pgarg antikoerper, Pp1158 antikoerper, ANGPTL4 antikoerper, fiaf antikoerper, im:7144703 antikoerper, si:rp71-39b20.7 antikoerper, angiopoietin like 4 antikoerper, angiopoietin-like 4 antikoerper, ANGPTL4 antikoerper, Angptl4 antikoerper, angptl4 antikoerper

Hintergrund: ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

Gen-ID: 51129

UniProt: Q9BY76

Pathways: Regulation of Lipid Metabolism by PPARalpha