IDO1 Antikörper

Produktnummer ABIN5688821

Produktdetails anti-IDO1 Antikörper

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IDO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Recognizes human IDO. Detects a band of ~45  kDa by Western blot. Other species not tested.

Immunogen: Recombinant human IDO.

Klon: ID 177

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: ELISA: (direct or indirect: 1:2,000-1:10,000). Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05 % Tween 20 and 5 % skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. 0.2um-filtered solution in PBS,  pH 7.4. Contains no preservatives.

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least 1 year after receipt when stored at -20°C.

Details zu IDO1

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Andere Bezeichnung: IDO (IDO1 Produkte)

Synonyme: INDO antikoerper, ido antikoerper, indo antikoerper, IDO antikoerper, cd107b antikoerper, IDO1 antikoerper, IDO-1 antikoerper, Ido antikoerper, Indo antikoerper, indoleamine 2,3-dioxygenase 1 antikoerper, indoleamine 2,3-dioxygenase 1 L homeolog antikoerper, indoleamine 2,3-dioxygenase 1-like antikoerper, IDO1 antikoerper, ido1.L antikoerper, ido1 antikoerper, Ido1 antikoerper, LOC100050681 antikoerper

Hintergrund: IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.

Gen-ID: 3620

NCBI Accession: NP_002155

UniProt: P14902

Pathways: Activated T Cell Proliferation