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Rekombinanter ITGA5 (Volociximab Biosimilar) Antikörper

Reaktivität: Human FACS, IF, ELISA, IHC, BR Wirt: Human Monoclonal M200 unconjugated Recombinant Antibody
Produktnummer ABIN5668270
  • Target
    ITGA5 (Volociximab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    Human
    Wirt
    • 2
    • 1
    • 1
    Human
    Klonalität
    • 4
    Monoklonal
    Konjugat
    • 4
    Unkonjugiert
    Applikation
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Immunohistochemistry (IHC), Blocking Reagent (BR)
    Spezifität
    The antibody binds to human α5β1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM.
    Produktmerkmale

    OriginalSpeciesName: Human

    OriginalFormat: IgG4

    Aufreinigung
    Purified antibody.
    Reinheit
    > 98 % as determined by SDS-PAGE
    Endotoxin-Niveau
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    Heterodimeric alpha5beta1Fc fusion protein
    Klon
    M200
    Isotyp
    IgG4 kappa
  • Applikationshinweise
    The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
    Kommentare

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    ITGA5 (Volociximab Biosimilar)
    Synonyme
    CD49e antikoerper, FNRA antikoerper, VLA5A antikoerper, integrin subunit alpha 5 antikoerper, ITGA5 antikoerper
    Substanzklasse
    Biosimilar
    Hintergrund
    Fibronectin receptor, CD49 antigen-like family member E, Integrin alpha-F, VLA-5, CD49e.
    UniProt
    P08648
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