Rekombinanter IL-6R (Tocilizumab Biosimilar) Antikörper
Reaktivität: Human
ELISA, InhA
Wirt: Human
Monoclonal
RhPM-1
unconjugated
Recombinant Antibody
(1 reference)-
- Target Alle IL-6R (Tocilizumab Biosimilar) Produkte
- IL-6R (Tocilizumab Biosimilar)
- Antikörpertyp
- Recombinant Antibody
- Reaktivität
- Human
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Wirt
-
Human
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Klonalität
- Monoklonal
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Konjugat
- Dieser IL-6R (Tocilizumab Biosimilar) Antikörper ist unkonjugiert
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Applikation
- ELISA, Inhibition Assay (InhA)
- Spezifität
- Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
- Produktmerkmale
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OriginalSpeciesName: Human
OriginalFormat: IgG1
- Aufreinigung
- Purified antibody.
- Reinheit
- > 98 % as determined by SDS-PAGE
- Endotoxin-Niveau
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
- Klon
- RhPM-1
- Isotyp
- IgG1 kappa
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anti-IL-6R (Tocilizumab Biosimilar) antibody
Reaktivität: Human ELISA, InhA Wirt: Kaninchen Monoclonal RhPM-1 unconjugated Recombinant Antibody
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- Applikationshinweise
- Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
- Kommentare
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % Proclin 300.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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-
: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).
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: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).
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- Target
- IL-6R (Tocilizumab Biosimilar)
- Abstract
- IL-6R (Tocilizumab Biosimilar) Produkte
- Synonyme
- CD126 antikoerper, IL-6R-1 antikoerper, IL-6RA antikoerper, IL6Q antikoerper, IL6RA antikoerper, IL6RQ antikoerper, gp80 antikoerper, interleukin 6 receptor antikoerper, IL6R antikoerper
- Substanzklasse
- Biosimilar
- Hintergrund
- IL6R, MRA, atlizumab
- UniProt
- A0N0L5
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