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Rekombinanter RSV (Felvizumab Biosimilar) Antikörper

Reaktivität: Respiratory Syncytial Virus (RSV) ELISA, Func Wirt: Kaninchen Monoclonal RSHZ19 unconjugated Recombinant Antibody
Produktnummer ABIN5668207
  • Target Alle RSV (Felvizumab Biosimilar) Produkte
    RSV (Felvizumab Biosimilar)
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    Respiratory Syncytial Virus (RSV)
    Wirt
    • 1
    • 1
    Kaninchen
    Klonalität
    • 2
    Monoklonal
    Konjugat
    • 2
    Dieser RSV (Felvizumab Biosimilar) Antikörper ist unkonjugiert
    Applikation
    ELISA, Functional Studies (Func)
    Spezifität
    This antibody is specific for the conserved fusion (F) protein of RSV.
    Produktmerkmale

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Aufreinigung
    Purified antibody.
    Reinheit
    > 98 % as determined by SDS-PAGE
    Endotoxin-Niveau
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
    Klon
    RSHZ19
    Isotyp
    IgG kappa
  • Applikationshinweise
    Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
    Kommentare

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    RSV (Felvizumab Biosimilar)
    Abstract
    RSV (Felvizumab Biosimilar) Produkte
    Substanzklasse
    Biosimilar
    Hintergrund
    SB 209763, respiratory syncytial virus
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