METTL14 Antikörper (AA 2-36)

Produktnummer ABIN5647669

Produktdetails anti-METTL14 Antikörper

Target: METTL14 (Methyltransferase Like 14 (METTL14))

Bindungsspezifität: AA 2-36

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser METTL14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität (Details): Expected species reactivity: Bovine

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 2-36 from the N-terminal region of the human protein was used as the immunogen for the METTL14 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the METTL14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western Blot: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the METTL14 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu METTL14

Target: METTL14 (Methyltransferase Like 14 (METTL14))

Andere Bezeichnung: METTL14 (METTL14 Produkte)

Synonyme: RGD1304822 antikoerper, G430022H21Rik antikoerper, mKIAA1627 antikoerper, zgc:77296 antikoerper, methyltransferase like 14 antikoerper, methyltransferase like 14 L homeolog antikoerper, Mettl14 antikoerper, mettl14.L antikoerper, METTL14 antikoerper, mettl14 antikoerper

Hintergrund: N6-adenosine-methyltransferase subunit METTL14 is an N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs.

UniProt: Q9HCE5