Splicing Factor 1 Antikörper

Produktnummer ABIN5647270

Produktdetails anti-Splicing Factor 1 Antikörper

Target: Splicing Factor 1 (SF1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Splicing Factor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity purified

Immunogen: A recombinant human protein corresponding to amino acids R160-Q266 was used as the immunogen for the SF1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SF1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the SF1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Splicing Factor 1

Target: Splicing Factor 1 (SF1)

Andere Bezeichnung: SF1 / Splicing factor 1 (SF1 Produkte)

Synonyme: BBP antikoerper, D11S636 antikoerper, MBBP antikoerper, ZCCHC25 antikoerper, ZFM1 antikoerper, ZNF162 antikoerper, BB094781 antikoerper, CW17R antikoerper, MZFM antikoerper, WBP4 antikoerper, Zfp162 antikoerper, CG5836 antikoerper, Dmel\\CG5836 antikoerper, cg5836 antikoerper, dSF1 antikoerper, p70 antikoerper, SF1 antikoerper, sf1 antikoerper, wu:fc09f06 antikoerper, znf162 antikoerper, MWD22.25 antikoerper, MWD22_25 antikoerper, SF-1 antikoerper, splicing factor 1 antikoerper, Splicing factor 1 antikoerper, splicing factor-like protein antikoerper, nuclear receptor subfamily 5 group A member 1 antikoerper, splicing factor 1 S homeolog antikoerper, SF1 antikoerper, Sf1 antikoerper, sf1 antikoerper, AT5G51300 antikoerper, NR5A1 antikoerper, sf1.S antikoerper

Hintergrund: Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene. This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.

UniProt: Q15637

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Maintenance of Protein Location